Since the mid-1930s Dębica, despite its size, has been a large industrial hub. A number of companies were then created thanks to governmental industry development programs. Most of them still exist today, though they were privatized in the 1990s:
- Firma Oponiarska Dębica S.A. (Tire Company Dębica) now owned by Goodyear Tire and Rubber Company, previous name - Stomil Dębica
- Lerg S.A. - a chemical manufacturer located in the village of Pustków, a village in Dębica County
- Tikkurila Polska S.A. (formerly Polifarb Dębica) - a paint manufacturer
- Wytwórnia Urządzeń Chłodniczych WUCh (Freezer Appliances Producer WUCh)
- Zakłady Mięsne (Meatworks)